4/26/2023 0 Comments Affinity photo nik collection![]() ![]() ![]() Adipocyte-specific TBK1 knockout (ATKO) attenuates HFD-induced obesity by increasing energy expenditure further studies show that TBK1 directly inhibits AMPK to repress respiration and increase energy storage. Tbk1 expression is increased in adipocytes of HFD-fed mice. Here, we report that the kinase uniquely controls energy metabolism. The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory cytokines, but its role in controlling metabolism remains unclear. ![]()
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